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VECTEUR D'EXPRESSION DE RÉCEPTEUR D'ANTIGÈNE CHIMÉRIQUE, ET CELLULE T D'EXPRESSION DE RÉCEPTEUR D'ANTIGÈNE CHIMÉRIQUE
专利权人:
Yamaguchi University
发明人:
申请号:
EP15849416.1
公开号:
EP3205720A1
申请日:
2015.10.06
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
An object of the present invention is to provide CAR-expressing T cells that coexpress a chimeric antigen receptor (CAR) and a T cell immune function-enhancing factor and have a high immunity-inducing effect and antitumor activity, and to provide a CAR expression vector for the preparation of the CAR-expressing T cells. A CAR expression vector comprises a nucleic acid encoding a chimeric antigen receptor (CAR) and a nucleic acid encoding a T cell immune function-enhancing factor, wherein the nucleic acid encoding an immune function-enhancing factor is a nucleic acid encoding interleukin-7 and a nucleic acid encoding CCL19, a nucleic acid encoding a dominant negative mutant of SHP-1, or a nucleic acid encoding a dominant negative mutant of SHP-2, or a CAR-expressing T cell introduced with the CAR expression vector are prepared.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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