Theravectys;Institut Curie;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;Université Pierre et Marie Curie;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
发明人:
申请号：
EP19159129.6
公开号：
EP3511413A1
申请日:
2015.07.24
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
The invention relates to the regulated expression of a chimeric antigen receptor (CAR) within a lentiviral vector. The CAR comprises a hook-binding domain that interacts with a hook, preferably encoded by the same lentiviral vector, which prevents proper processing and release of the CAR to the cell membrane. The invention encompasses vectors, methods of making the vectors, and methods of using them, including medicinal uses. The vectors can be used for administration to humans to induce immune responses and to treat cancers and tumors. The invention in particular relates to an isolated cell comprising a nucleic acid molecule, a nucleic acid vector or a lentiviral vector encoding a CAR and a method for expressing the CAR in a cell.
