A compound of formula I, a stereoisomer thereof, a cis-trans isomer thereof, a tautomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof, or a solvate thereof, ** ** Formula wherein: R1 is selected from the group consisting of C1-C6 alkylacylamino, I alquenilacilamino C2-C6, I alquinilacilamino C2-C6, C6-C18 arilacilamino and amino substituted with C1-C6 alkyl R2 and R3 each independently selected from the group consisting of hydrogen, C7-C24, aryl C6-C18 substituted or unsubstituted heteroaryl C5-C18 substituted or unsubstituted, in which a substituent on the aryl is selected from the group consisting of C2-C6 alkynyl, halogen, C7-C24 aralkyloxy, heteroaralkyloxy C6-C24 aryloxy and heteroaryloxy C6-C18-C18 C5, and a substituent on the heteroaryl is selected from the group consisting of C24 C7- aralkyl, C6 arilacilamino C18, C6-C18 arylsulfonylamino, heteroarilacilamino C5-C18, C3-C10 cicloalquilacilamino, arilaminoacilo C6-C18, C7-C24 aralkyloxy, heteroaralkyloxy C6-C24 aryloxy and C6-C18 or R2 and R3 together with the nitrogen atom to which they are attached form a C3-C18 substituted or unsubstituted heterocyclyl and R4 is heterocyclyl C3-C18 substituted or unsubstituted heteroaryl or C5-C18 substituted or unsubstituted.Un compuesto de fórmula I, un estereoisómero del mismo, un isómero cis-trans del mismo, un tautómero del mismo, o una mezcla de los mismos, o una sal farmacéuticamente aceptable del mismo, o un solvato del mismo,**Fórmula** en la que: R1 se selecciona del grupo que consiste en alquilacilamino C1-C6, alquenilacilamino C2-C6, alquinilacilamino C2-C6, arilacilamino C6-C18 y amino sustituido con alquilo C1-C6 R2 y R3 se seleccionan cada uno independientemente del grupo que consiste en hidrógeno, aralquilo C7-C24, arilo C6-C18 sustituido o sin sustituir, heteroarilo C5-C18 sustituido o sin sustituir, en el que un sustituyente en el arilo se selecciona del grupo que consiste en alquinilo C2-C6, halógeno, aralquiloxi C7-C24, he
