PROBLEM TO BE SOLVED: To provide a high-pressure water vapor sterilization method, capable of obtaining a sterilized article in which adhesion of moisture and defects of solid foreign objects are effectively prevented in a short period of time without requiring a large volume of energy.SOLUTION: A high-pressure water vapor sterilization method is for obtaining a sterilized object by exposing an object to be sterilized such as a medical article to a high-temperature and high-pressure water vapor environment and sterilizing the object to be sterilized with water vapor. The object to be sterilized is enclosed inside a microorganism-impermeable package material having a water vapor permeable part at least in a part to form a package body. The object to be sterilized is pre-heated to 50-110°C before exposing the object to be sterilized to high-temperature and high-pressure water vapor, and after that, high-temperature and high-pressure water vapor is introduced into the package body from the water-vapor permeable part of the package material to sterilize the object to be sterilized with high-pressure water vapor. The high-pressure water vapor sterilization method is characterized by obtaining the package body with the sterilized object enclosed in the microorganism-impermeable package material by sterilizing the object to be sterilized with high-pressure water vapor.COPYRIGHT: (C)2014,JPO&INPIT【課題】多大なエネルギーを要することなく、短時間に、水分の付着や固形異物不良が有効に防止された滅菌済物品を得ることができる高圧水蒸気滅菌方法を提供する。【解決手段】医療用品を滅菌対象とし、滅菌対象を高温・高圧の水蒸気雰囲気に晒して高圧水蒸気滅菌することにより、滅菌済物品を得る高圧水蒸気滅菌方法である。少なくとも一部に水蒸気透過部を有する、微生物不透過性の包装材の内部に、滅菌対象を封入して包装体を形成し、滅菌対象を高温・高圧の水蒸気に晒す前に、滅菌対象を50~110℃に予備加熱し、その後、包装材の水蒸気透過部から包装体の内部に高温・高圧の水蒸気を導入し、滅菌対象を高圧水蒸気滅菌することにより、滅菌済物品が微生物不透過性の包装材の内部に封入された包装体を得ることを特徴とする高圧水蒸気滅菌方法。【選択図】図1