PROBLEM TO BE SOLVED: To provide a material in which a spiny dogfish in which there is a dietary habit and that is safe is used, and a side effect is few based on onset mechanism of osteoporosis, that promotes growth of osteoblast enabling extended administration, and that has an effect to treating and prevention to aim at osteogenesis.SOLUTION: A bone remodeling improvement medicine uses a spiny dogfish head cartilage or a defatting object thereof as an active ingredient, can improve an osteoblast activity level by as much as 20-30% and improve an osteoclast activity level by as much as 20% without decreasing a serum calcium level by administration. Moreover, an osteogenesis promoter, an osteogenesis promotion food, and an osteoporosis preventive food use the spiny dogfish head cartilage or the defatting object of the same as an active ingredient.COPYRIGHT: (C)2014,JPO&INPIT【課題】食習慣があり安全であるアブラツノザメを利用して、骨粗鬆症の発症メカニズムを踏まえて、副作用が少なく、長期投与可能な骨芽細胞の増殖を促進し、骨形成を目的とした治療や予防に効果を有する素材を提供すること。【解決手段】アブラツノザメ頭部軟骨またはその脱脂物を有効成分として用い、投与により血中カルシウム値を低下させることなく骨芽細胞活性レベルを20~30%も改善し、また破骨細胞活性レベルを20%も改善させることのできる骨リモデリング改善剤とする。また、アブラツノザメ頭部軟骨またはその脱脂物を有効成分として用い、骨形成促進剤や骨形成促進食品、骨粗鬆症予防食品とする。【選択図】図1
