Provision of bone formation enhancers, including the RANKL action molecules that enhance the differentiation and maturation, calcification of cells that can differentiate into osteoblasts or osteoblast. And comprising as an active ingredient, a compound that promotes mineralization differentiation of cells acts on RANKL on cells that can differentiate into osteoblasts or osteoblast cells, capable of differentiating into osteoblasts or osteoblast proliferation, or mature, A pharmaceutical composition for the treatment or prevention of metabolic bone diseases associated with bone loss.骨芽細胞又は骨芽細胞に分化し得る細胞の分化・成熟・石灰化を増強するRANKL作用分子を含む骨形成増強剤の提供。骨芽細胞又は骨芽細胞に分化し得る細胞上のRANKLに作用し、骨芽細胞又は骨芽細胞に分化し得る細胞の分化、増殖、成熟又は石灰化を促進する化合物を有効成分として含む、骨量減少を伴う骨代謝疾患の治療又は予防のための医薬組成物。
