PROBLEM TO BE SOLVED: To provide an osteogenesis enhancer comprising a molecule of acting on RANKL that enhances differentiation, maturation, or calcification of osteoblasts or cells capable of differentiating into osteoblasts.SOLUTION: A pharmaceutical composition for treatment or prevention of metabolic bone diseases accompanied by the decrease in bone mass contains, as an active ingredient, a compound that acts on RANKL located on osteoblasts or cells capable of differentiating into osteoblasts and promotes differentiation, proliferation, maturation, or calcification of osteoblasts or cells capable of differentiating into osteoblasts.【課題】骨芽細胞又は骨芽細胞に分化し得る細胞の分化・成熟・石灰化を増強するＲＡＮＫＬ作用分子を含む骨形成増強剤の提供。【解決手段】骨芽細胞又は骨芽細胞に分化し得る細胞上のRANKLに作用し、骨芽細胞又は骨芽細胞に分化し得る細胞の分化、増殖、成熟又は石灰化を促進する化合物を有効成分として含む、骨量減少を伴う骨代謝疾患の治療又は予防のための医薬組成物。【選択図】なし
