Laurence J. N. Cooper,Ana Beatriz Korngold,Brian A. Rabinovich,Harjeet Singh,Simon Olivares
申请号：
US15118245
公开号：
US10125193B2
申请日:
2015.02.16
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Provided are methods of generating chimeric antigen receptors (CAR). In some embodiments, library screening of CAR is performed by generating a vector encoding the CAR from random attachment of vectors from libraries of vectors encoding antigen-binding domains (e.g., scFv regions), hinge regions, and endodomains. In some embodiments, the vectors contain a transposon.
