PROBLEM TO BE SOLVED: To provide a substance capable of promoting the CGRP responsiveness of cells.SOLUTION: A CGRP responsiveness promoter of cells includes Lignans represented by formula (I) (in the formula (I), Rrepresents a hydrogen atom or an alkoxy group, and R, Rand Rmay be the same or different each represent an alkoxy group) as an active ingredient.【課題】細胞のＣＧＲＰ応答性を促進することができる素材の提供。【解決手段】下記式（Ｉ）で表されるリグナン類を有効成分とする細胞のＣＧＲＰ応答性促進剤（式（Ｉ）中、Ｒ1は水素原子又はアルコキシ基を示し、Ｒ2、Ｒ3及びＲ4は、同一又は異なって、アルコキシ基を示す）。【化１】【選択図】なし
