Durgesh V. Nadkarni,Jeffry R. Borgmeyer,He Meng,Qingping Jiang
申请号：
US15778290
公开号：
US20190367556A1
申请日:
2016.12.07
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Methods of removing high molecular weight species, in particular aggregates, from antibody drug conjugate preparations, by contacting preparations of the antibody drug conjugate reaction mixture with a hydroxyapatite resin and selectively eluting the ADC from the resin using a gradient comprising sodium phosphate.
