Ugur Sahin,Andreas Kuhn,Edward Darzynkiewicz,Jacek Jemielity,Joanna Kowalska
申请号：
US13388560
公开号：
US09295717B2
申请日:
2010.08.03
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention relates to modification of RNA with 5′-cap analogs of Formula (1):wherein R1-R6 and n are as described herein, in order to improve the stability and increase the expression of said RNA, in particular in immature antigen presenting cells. The present invention provides a vaccine composition comprising said stabilized RNA, immature antigen presenting cells comprising said stabilized RNA, and methods for stimulating and/or activating immune effector cells and for inducing an immune response in an individual using said stabilized RNA.
