A method is provided for inducing or enhancing an immune response in a mammal to atarget polypeptide expressed in a plurality of cells of the mammal, which method comprisesadministering to the mammal an inhibitory nucleic acid which targets a regionof a ribonucleic acid (RNA) which encodes said polypeptide. Also provided isa pharmaceutical composition comprising an inhibitory nucleic acid which targetsa region of an RNA which encodes a target polypeptide expressed in a plurality ofcells of a mammal, such that translation of an aberrant form of the target polypeptide occursin said cells, said truncated form of the target polypeptide comprising one ormore T cell epitopes； together with a pharmaceutically acceptable carrier ordiluent.
