A method of determining the histological grade of Hepatocellular Carcinoma (HCC) including: acquiring a Computed Tomography (CT) image of a person including an HCC tumor delineating the HCC tumor and assigning a histological grade to the HCC tumor, wherein assigning the histological grade to the HCC tumor includes: applying a plurality of filters to the HCC tumor, wherein each of the filters produces a corresponding response image and, for each of the filters, a convolution operation is performed on the filter and the CT image to produce the response image corresponding to that filter computing an average response of the HCC tumor in each of the response images and recording each of the average responses as an Independent Subspace Analysis (ISA) feature and determining the histological grade of the HCC tumor based on the ISA features by using a classifier.
