Embodiments of the present disclosure are directed to a system for generating three-dimensional images of a target region of a patient. The system may include at least one computer system. The computer system may be configured to receive a plurality of non-parallel projection images of the target region of the patient, convert the plurality of non-parallel projection images into a non-spatial domain, reconstruct a three-dimensional image from the plurality of non-parallel projection images in the non-spatial domain, and convert the reconstructed three-dimensional image from the non-spatial domain to the spatial domain.
