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SHORT ANTIMICROBIAL lipopeptides
专利权人:
ИНК. (US);ХЕЛИКС БАЙОМЕДИКС
发明人:
ЧЖАН Лицзюань (US),КАРМАЙКЛ Робин (US)
申请号:
RU2014142038
公开号:
RU2014142038A
申请日:
2013.03.07
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A peptide of the formula: Slipid-lysine-proline-N; Slipid-lysine-d-proline-NH; Slipid-lysine-histidine-NH or Slipid-lysine-arginine-NH. 2. The peptide according to claim 1, wherein the Slipid is a lipid fragment of lauric acid (C12), myristic acid (C14), pentadecanoic acid (C15), palmitic acid (C16) or stearic acid (C18). 3. The peptide according to claim 1, wherein the peptide is palmitoyl-lysine-proline-NH; palmitoyl-lysine-d-proline-NH; palmitoyl-lysine-histidine-NH or lipalmitoyl-lysine-arginine-NH. 4. A composition comprising at least one peptide according to any one of paragraphs. 1-3 and a pharmaceutically acceptable carrier. 5. A composition according to claim 4, wherein the peptide is present in a concentration in the range of from about 0.1 μg / ml to about 10% (w / v). A composition according to claim 4 or 5, wherein the composition is in the form of an aerosol, cosmetic preparation, spray, emulsion, liquid, lotion, cream, paste, ointment, powder or foam. A composition according to claim 6, which can be used to prevent or treat skin conditions of acne, atopic dermatitis, rosacea, bacterial vaginosis, dandruff or epidermophytosis of the feet. A method for the prevention or treatment of a microbial infection of a skin or mucous tissue in a mammal, comprising administering to the infected area of said mammal a therapeutically effective amount of a composition according to any one of claims. 4-7 for an effective amount of time. 9. The method of claim 8, wherein the therapeutically effective amount of the composition comprises a peptide in a concentration in the range of about 0.1 μg / ml to about 10% (w / v). The method of claim 8, wherein the microbial infection is caused by a bacterium selected from the group consisting of P. acnes, S. aureus, Ε. coli and C. albicans. 11. The method of claim 8, wherein the microbial infection of the skin is acne, atopic dermatitis, rosacea, bacterial vagina1. Пептид формулы:Cлипид-лизин-пролин-N;Cлипид-лизин-d-пролин-NH;
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