Substituted 3- (thiazole-4-carbonyl)-or 3- (thiazole-2-carbonyl) -aminopropionic acid derivatives and their use as medicaments

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专利权人:

サノフイ

发明人:

スヴェン・ルフ,ヨーゼフ・ペルナーシュトルファー,トールステン・ザドウスキー,ゲオルク・ホルスティック,ヘルマン・シュローダー,クリスティアン・ブニング,クラウス・ヴィルト

申请号：

JP2014522087

公开号：

JP5989112B2

申请日:

2012.07.25

申请国别(地区):

JP

年份:

2016

代理人:

摘要：

The present invention relates to compounds of the formulae Ia and Ib, wherein G, R10, R30, R40, R50 and R60 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. They are inhibitors of the protease cathepsin A, and are useful for the treatment of diseases such as atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases, for example. The invention furthermore relates to processes for the preparation of the compounds of the formulae Ia and Ib, their use and pharmaceutical compositions comprising them.

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