[1H-INDOL-5-IL) HETEROARILOXI] - (1-AZA-BICICLO [3.3.1] NONANS AS N-ACHR COLLINERIC LIGANDS FOR THE TREATMENT OF SYNCHOTIC AND NEURODEGENERATIVE DISORDERS.

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专利权人:

NOVARTIS AG

发明人:

FEUERBACH, DOMINIK,FREDERIKSEN, MATHIAS,HURTH, KONSTANZE,ROY, BERNARD,WAGNER, BEATRIX

申请号：

ES06846986

公开号：

ES2375847T3

申请日:

2006.12.14

申请国别(地区):

ES

年份:

2012

代理人:

摘要：

A compound of the formula (I) wherein X represents hydrogen or hydroxyl and Y represents one of the following groups: in the form of free base or salt by acid addition, wherein said compound is selected from the group consisting of (4S, 5R) -4- [5- (1H-Indol-5-yl) -pyrimidin-2-yloxy] -1-aza-bicyclo [3.3.1] nonane, 5- {2- [(4S, 5R) - ( 1-Aza-bicyclo [3.3.1] non-4-yl) oxy] -pyrimidin-5-yl} -1,3-dihydro-indole-2- one, (4S, 5R) -4- [6- ( 1H-Indol-5-yl) -pyridin-3-yloxy] -1-aza-bicyclo [3.3.1] nonano, (4S, 5R) -4- [5- (1H-Indole-5-yl) -pyridin -2-yloxy] -1-aza-bicyclo [3.3.1] nonano, (4S, 5R) -4- [6- (1H-Indol-5-yl) -pyridazin-3-yloxy] -1-aza- bicyclo [3.3.1] nonano, and 5- {6- [(4S, 5R) - (1-Aza-bicyclo [3.3.1] non-4-yl) oxy] -pyridazin-3-yl} -1, 3-dihydro-indole-2- one.Un compuesto de la fórmula (I) en donde X representa hidrógeno o hidroxilo e Y representa uno de los siguientes grupos: en forma de base libre o sal por adición de ácido, en donde dicho compuesto se selecciona del grupo que consiste de (4S,5R) -4- [5-(1H-Indol-5-il) -pirimidin-2-iloxi] -1-aza-biciclo [3.3.1] nonano, 5-{2- [(4S,5R) -(1-Aza-biciclo [3.3.1] non-4-il)oxi] -pirimidin-5-il}-1,3-dihidro-indol-2- ona, (4S,5R) -4- [6-(1H-Indol-5-il) -piridin-3-iloxi] -1-aza-biciclo [3.3.1] nonano, (4S,5R) -4- [5-(1H-Indol-5-il) -piridin-2-iloxi] -1-aza-biciclo [3.3.1] nonano, (4S,5R) -4- [6-(1H-Indol-5-il) -piridazin-3-iloxi] -1-aza-biciclo [3.3.1] nonano, y 5-{6- [(4S,5R) -(1-Aza-biciclo [3.3.1] non-4-il)oxi] -piridazin-3-il}-1,3-dihidro-indol-2- ona.

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