YUM, SU IL,亚姆 苏,亞姆 蘇,CHAO, WENDY,乔 温蒂,喬 溫蒂,SU, HUEY-CHING,苏惠清,蘇惠清,FU, ROGER,傅 罗杰,傅 羅傑,ZAMLOOT, MICHAEL S.,山姆鲁 麦克,山姆魯 麥克,BRATIN, KARL,布雷霆 卡尔,布雷霆 卡爾,SHANKER, RAVI M.,萱可 拉维,萱可 拉維
申请号：
TW103109571
公开号：
TW201521769A
申请日:
2014.03.14
申请国别(地区):
TW
年份:
2015
代理人:
摘要：
The present disclosure provides compositions (e.g., extended release compositions) which exhibit a desirable pharmacokinetic profile of an active agent while providing reduced dissolution sample variability, e.g., in the form of reduced inter-capsule variability and/or a reduction in storage-time dependent change in mean release of the active agent from the composition. Related methods of making and administering the disclosed compositions are also provided.本發明提供一種組成物(例如延長釋放組成物),其展現合乎需要的活性劑之藥物動力學概況同時提供減少之溶解樣品變異性,例如呈減少之膠囊間變異性及/或活性劑自該組成物之平均釋放的儲存-時間依賴性變化減少之形式。亦提供製造及投與所揭示之組成物的相關方法。
