A method of blocking signal transmission through a nerve with reduced onsetactivity includes applying an HFAC toan axon of a nerve to block the transmission of signals through the axon. Themethod may also include applying a direct current (DC)to the axon, increasing the amplitude of the DC over time to a predeterminedamplitude, applying the HFAC, and then decreasingthe DC. The method may also include temporarily reducing the amplitude of theHFAC to permit the transmission of signals throughthe axon and subsequently increasing the amplitude to block transmissionwithout triggering an onset response. The method mayalso include temporarily applying an unbalanced charge to the nerve and thenbalancing the charge over time.
