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Multitargeting interfering RNAs having two active strands and methods for their design and use
专利权人:
Gregory Martin Arndt;Michael Poidinger;Laurent Pierre Rivory;Donald John Birkett;Toby Passioura
发明人:
Laurent Pierre Rivory,Michael Poidinger,Donald John Birkett,Gregory Martin Arndt,Toby Passioura
申请号:
US12124629
公开号:
US08097715B2
申请日:
2008.05.21
申请国别(地区):
US
年份:
2012
代理人:
摘要:
Interfering RNA molecules are now designed and produced with specificity for multiple binding sequences present in distinct genetic contexts in one or more pre-selected target RNA molecules and are used to modulate expression of the target sequences. The multitargeting interfering RNA molecules have two strands that target multiple target sites on one or more pre-selected RNA molecules. Such a multitargeting interfering RNA approach provides a powerful tool for gene regulation.
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