НИИЦУ Ёсиро (JP),ТАКАХАСИ Хирокадзу (JP),ТАНАКА Ясунобу (JP),ФАЙНШТЕЙН Елена (IL),АВКИН-НАЧУМ Шерон (IL),КАЛИНСКИ Хагар (IL),МЕТТ Игорь (IL)
申请号：
RU2013107129/10
公开号：
RU2013107129A
申请日:
2011.09.27
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A nucleic acid molecule, wherein: (a) said nucleic acid molecule contains sense and antisense strands； (b) each strand of a nucleic acid molecule independently contains from 15 to 49 nucleotides in length； (c) a sequence of antisense strands containing from 15 to 49 nucleotides complementary to an mRNA sequence encoding TIMP1 (SEQ ID NO: 1) or TIMP2 (SEQ ID NO: 2)； and (d) a sense strand sequence containing 15 to 49 nucleotides in length is complementary to the antisense strand sequence, thereby forming a duplex region, and contains a mRNA sequence of 15-49 nucleotides encoding TIMP1 (SEQ ID NO: 1) or TIMP2 (SEQ ID NO: 2) .2. The nucleic acid molecule according to claim 1, characterized in that the antisense strand is complementary to the mRNA sequence encoding human TIMP1 (SEQ ID NO: 1), and the antisense strand and sense strand include pairs of sequences selected from the group consisting of: siTIMP1_p2 (SEQ ID NO: 267 and 299)； siTIMP1_p6 (SEQ ID NO: 268 and 300)； siTIMP1_p14 (SEQ ID NO: 269 and 301)； siTIMP1_p16 (SEQ ID NO: 270 and 302)； siTIMP1_p17 (SEQ ID NO: 271 and 303)； siTIMP1_p19 (SEQ ID NO: 272 and 304)； siTIMP1_p20 (SEQ ID NO: 273 and 305), siTIMP1_p21 (SEQ ID NO: 274 and 306)； siTIMP1_p23 (SEQ ID NO: 275 and 307)； siTIMP1_p29 (278 and 310)； siTIMP1_p33 (280 and 312)； siTIMP1_p38 (SEQ ID NO: 281 and 313)； siTIMP1_p42 (282 and 314)； siTIMP1_p43 (SEQ ID NO: 283 and 315)； siTIMP1_p45 (284 and 316)； siTIMP1_p60 (SEQ ID NO: 286 and 318)； siTIMP1_p71 (SEQ ID NO: 287 and 319)； siTIMP1_p73 (SEQ ID NOS: 288 and 320)； siTIMP1_p78 (290 and 322)； siTIMP1_p79 (SEQ ID NO: 291 and 323)； siTIMP1_p85 (SEQ ID NO: 292 and 324)； siTIMP1_p89 (SEQ ID NO: 293 and 325)； siTIMP1_p91 (SEQ ID NO: 294 and 326)； siTIMP1_p96 (SEQ ID NO: 295 and 327)； siTIMP1_p98 (SEQ ID NO: 296 and 328)； siTIMP1_p99 (SEQ ID NO: 297 and 329) and siTIMP1_p108 (SEQ ID NO: 298 and 330) .3. The nucleic acid molecule according to claim 1, characterized in that the antisense strand is complementary to t
