DAVID HOOK,BERNHARD RISS,DANIEL KAUFMANN,MATTHIAS NAPP,ERHARD BAPPERT,PHILIPPE POLLEUX,JONATHAN MEDLOCK,ANTONIO ZANOTTI-GEROSA
申请号：
BRPI0906764
公开号：
BRPI0906764A2
申请日:
2009.01.16
申请国别(地区):
BR
年份:
2015
代理人:
摘要：
The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a gamma-amino-delta-biphenyl-alpha-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.
