Martin Peter Green;Toby James Underwood;Karl Richard Gibson;Florian Wakenhut
发明人:
Karl Richard Gibson,Martin Peter Green,Toby James Underwood,Florian Wakenhut
申请号：
US12561398
公开号：
US08232269B2
申请日:
2009.09.17
申请国别(地区):
US
年份:
2012
代理人:
摘要：
A compound of Formula (I), or a pharmaceutically acceptable salt or solvate thereof,wherein,R1 and R2 each independently represent H, halogen, CF3, C1-3 alkyl or C1-3 alkoxy；R3 represents C1-6 alkyl, C3-6 cycloalkyl, phenyl (optionally substituted by one or more substituents each independently selected from Ra) or Het (optionally substituted by one or more substituents each independently selected from OH, oxo, or C1-4 alkyl)；R4 represents H or C1-3 alkyl；R5 represents C1-6 alkyl (optionally substituted by one or more substituents each independently selected from Rb), C3-6 cycloalkyl (optionally substituted by one or more substituents each independently selected from oxo or OH), or Het2 (optionally substituted by one or more substituents each independently selected from Rd)； oxygen atom or 1 sulphur atom, or (c) 1 oxygen atom or 1 sulphur atom, (optionally substituted by one or more substituents each independently selected from OH, oxo or C1-4 alkyl)； andR6 represents C1-3 alkyl (optionally substituted by one or more substituents each independently selected from Rf), C3-5 cycloalkyl (optionally substituted by one or more halogen), CN or halogen； where Rf represents halogen or phenyl: and compositions, processes for the preparation, and uses thereof, e.g. in the treatment of endometriosis or uterine fibroids.
