Yosser Ben Achour,Mehdi Chenik,Hechmi Louzir,Koussay Dellagi
申请号：
US12056764
公开号：
US08715697B2
申请日:
2008.03.27
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention relates to the field of combating leishmaniases. Said invention results from the isolation, from wild isolates of Leishmania major, of a protein-coding gene known as LmPDI which has two regions that are identical to the sequence (Cys-Gly-His-Cys) of the potential active site of the protein disulphide isomerase (PDI). The LmPDI protein is predominantly expressed in the most virulent isolates of the parasite. Said protein forms a novel therapeutic target for developing anti-leishmaniasis medicaments and a novel element that can be used in the composition of immunogenic, and possibly vaccinating, preparations which are intended to protect a human or animal host against Leishmania.
