Li Chen,Michael Patrick Dillon,Lichun Feng,Ronald Charles Hawley,Minmin Yang
申请号:
US15093320
公开号:
US09617254B2
申请日:
2016.04.07
申请国别(地区):
US
年份:
2017
代理人:
摘要:
Compounds of the formula I:or a pharmaceutically acceptable salt thereof, wherein, R1 is a group of formula A or formula B,and X, R2, R3, R4, R5, R6, Ra and Rb are as defined herein. Also provided are methods of using the compounds for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist and methods of making the subject compounds.