A method for the preparing mixtures of pharmaceutical or biopharmaceutical substances (11, 11″) includes arranging a preparation container (3, 3′, 3″) already made up with ingredients in a receptacle (2) of a device (1, 1′, 1″) feeding a fluid (10) from a storage container (4, 4″) into the preparation container (3, 3″) via a feed line (6), preparing the ingredients with the fluid (10, 10″) into a substance mixture (11, 11″), and removing the substance mixture (11, 11″) from the preparation container (3, 3′, 3″) into a receiving container via a discharge line (12, 12′, 12″). A device also is provided for carrying out the method.