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GROWTH HORMONE RELEASING PEPTIDES
专利权人:
IPSEN PHARMA S.A.S.
发明人:
DONG, ZHENG, XIN
申请号:
SG2007033848
公开号:
SG177006A1
申请日:
2003.08.08
申请国别(地区):
SG
年份:
2012
代理人:
摘要:
GROWTH HORMONE RELEASING PEPTIDES ABSTRACTDisclosed are peptide and peptidomimetic compounds generally according to formula (I), and pharmaceutically acceptable salts thereof, that are useful as GHRP analogs:R[err]A[err]A[err]A[err]A[err] A[err]R[err] (I) or a pharmaceutically acceptable salt thereof, wherein:A[err] is Aib, Apc or Inp;A[err] is D-Bal, D-Bip, D-Bpa, D-Dip, D-1 Nal, D-2NaI, D-Ser(Bzl), or D-Trp; A[err] is D-Bal, D-Bip, D-Bpa, D-Dip, D-1 Nal, D-2Nal, D-Ser(Bzl), or D-Trp; A[err] is 2Fua, Orn, 2Pal, 3Pal, 4Pal, Pff, Phe, Pim, Taz, 2Thi, 3Thi, Thr(Bzl); A[err] is Apc, Dab, Dap, Lys, Orn, or deleted;R[err] is hydrogen, (C1-6)alkyl, (C5-14)aryl, (C1-6)alkyl(C5-14)aryl, (C3-8)cycloakyl, or (C2-1 O)acyl; andR[err] is OH or NH[err];and pharmaceutical compositions and methods of use thereof.
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