AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人:
KIM, YONG SUNG,KIM, YE JIN,JUNG, KEUNOK,KIM, JEONG-AH
申请号：
CA3075403
公开号：
CA3075403A1
申请日:
2018.09.07
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The present invention relates to a composition for inhibiting the immunosuppression of regulatory T cells (Treg), using a fusion protein inclusive of a peptide binding specifically to neuropilin 1 (NRP1). A fusion protein inclusive of a peptide binding specifically to neuropilin 1 according to the present invention reduces a proportion of regulatory T cells of CD4+ T cells in a tumor tissue and restrains the activity of regulatory T cells that have penetrated into a tumor tissue, thereby downregulating the immunosuppression in the tumor tissue without systemic toxicity and thus can be expected to exert a high therapeutic effect on a tumor.
