The present disclosure provides co-crystals of a substituted glycine compound and a co-former compound of Formula (I):, compositions comprising such, and uses thereof in treating and/or reducing the risk for a neuropsychiatric disorder (e.g., schizophrenia, psychotic disorders, depressive disorders, suicidal ideation and/or behavior, obsessive compulsive disorder or Alzheimer’s disease). Also provided herein are methods for preparing the co-crystals.本揭示內容提供一種經取代的甘胺酸化合物與式(I):共形物之共晶、包含該共晶之組合物以及其用於治療及/或減少罹患神經精神疾病(例如精神分裂症、精神病疾患、憂鬱症、自殺意念及/或行為、強迫症或阿茲海默症)之風險的用途。本揭示內容亦提供製備該共晶的方法。