Fibrin sealant (FIBRINGLURAAS®) consisting of a kit of lyophilized high concentrate fribinogen intentionally enriched and preserved with fibrinolysis inhibitor A1AT, either non-heated or heating to at least 1℃ and above, preferably at least 101℃, and lyophilized thrombin used to compound glue membrane, the diameter of which is less than 10 micrometers the actual size of the glue membrane of the fibrin sealant (FIBRINGLURAAS®) is from 0.6μm, to 101℃ heating 0.005 micrometers. Thrombin, a protein, contains good healthy cells. High concentrate fibrinogen, another protein, contains good healthy cells. AFOD (HDL ApoA1), another protein, contains good healthy cells and its topical applications for all solid tumor cancers.本發明係有關於由故意增富且保留纖維蛋白分解抑制劑A1AT之冷凍乾燥的高濃縮纖維蛋白原套組,其可未經加熱或加熱到至少1℃及更高的溫度、較佳至少101℃,以及用以配混膠膜之冷凍乾燥的凝血酵素所構成之纖維蛋白密封劑(FIBRINGLURAAS®),其直徑小於10微米,該纖維蛋白密封劑(FIBRINGLURAAS®)之膠膜的實際大小為自0.6微米至101℃加熱之0.005微米。凝血酵素(一蛋白質)含有良好健康的細胞。高濃縮纖維蛋白原(另一蛋白質)含有良好健康的細胞。AFOD(HDL ApoA1)(另一蛋白質)含有良好健康的細胞且其可局部施用於所有固態腫瘤癌。