INSTITUTE OF NUCLEAR ENERGY RESEARCH;NATIONAL HEALTH RESEARCH INSTITUTES;INSTITUTE OF NUCLEAR ENERGY RESEARCH, AEC; AEC
发明人:
LEE, TE WE,李德伟,李德偉,张雅珍,張雅珍,陈亮丞,陳亮丞,YU, CHIU YU,游佳瑜,CHIU, SHU PEI,邱淑佩,邱淑珮,陈淑玲,陳淑玲,CHANG, CHIH-HSIEN,张志贤,張志賢,LUO, TSAI YUEH,罗彩月,羅彩月,TING, GANN,丁干,丁幹
申请号：
TW096110033
公开号：
TWI399222B
申请日:
2007.03.23
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
The present invention is that difunctional and economic benefits and social benefits nanometer target set group (kit) is composed of radiopharmaceuticals and chemotherapeutic agent, this set group includes three parts: (1) A bottles-its formula components include BMEDA, gluconate acetate, SnCl2 etc.. (2) B bottles-its formula components include DSPC, cholesterol, DSPE-PEG, Doxorubicin (DXR) or Daunorubicin or Vinolbine etc.. (3) C bottles of -188ReO4- (or 186ReO4-) solution. It is difunctional with economic benefits and social benefits nanometer target set group method using this combined type: (1) from C bottles of taking-up 188ReO4- (or 186ReO4-) solution, (2) 188ReO4- (or 186ReO4-) solution is injected A bottles and reacted at a proper temperature, (3) remove 188Re-BMEDA (or 186Re-BMEDA) solution from A bottles. (4) 188Re-BMEDA or 186Re-BMEDA solution is injected B bottles, and by heating reaction, the difunctional micro- rouge body drug with economic benefits and social benefits nanometer target angiographic diagnosis and radiotherapy and chemotherapy of combined type is then obtained, can be used as angiographic diagnosis and treats the application of tumour or malignant tumour ascites.本發明是由放射藥物與化學治療藥物組合而成雙功能與雙效奈米標靶套組(kit)，此套組包括三個部份：(1)A瓶-其配方成分包括BMEDA、gluconate acetate、SnCl2等。(2)B瓶-其配方成分包括DSPC、cholesterol、DSPE-PEG、Doxorubicin(DXR)或Daunorubicin或Vinolbine等。(3)C瓶-188ReO4-(或186ReO4-)溶液。使用此組合式雙功能與雙效奈米標靶套組方法：(1)從C瓶取出188ReO4-(或186ReO4-)溶液，(2)將188ReO4-(或186ReO4-)溶液注入A瓶並在適當的溫度下反應，(3)從A瓶中移出188Re-BMEDA(或186Re-BMEDA)溶液。(4)將188Re-BMEDA或186Re-BMEDA溶液注入B瓶，並經過加熱反應，則得到組合式雙功能與雙效奈米標靶造影診斷與放射治療及化學治療之微脂體藥物，可做為造影診斷與治療腫瘤或惡性腫瘤腹水之應用。
