THE UNITED STATE OF AMERICA; AS REPRESENTED BY THE SECRETARY OF AGRICULTURE
发明人:
Donovan, David M.
申请号：
AU2009273845
公开号：
AU2009273845B2
申请日:
2009.07.24
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
Multi-drug resistant superbugs are a persistent problem in modern health care. This invention provides an antimicrobial endolysin - Lysostaphin triple fusion protein, comprising (1) an endolysin CHAP endopeptidase domain, (2) an endolysin amidase domain, and (3) a Lysostaphin glycyl-glycine endopeptidase domain. The domains are derived from two proteins that show antimicrobial synergy when used in combination. The protein has specificity and exolytic activity for the peptidoglycan cell wall of untreated, live
