A construct for expression in a T cell, the construct providing an antigen receptor chimera (TARC) protein, incorporating the antigen-binding specificity of an alpha beta T cell receptor with a costimulatory-only endodomain is described. The construct may be expressed in gamma delta T cells as shown in the figure or Natural Killer (NK) cells which can allow a tunable response to be provided in such modified cells. Also provided are methods of using such modified cells, and pharmaceutical compositions comprising the same.
