By inhibiting the activity of PI3K, to control cell growth, differentiation, survival, proliferation, metabolism and the like migration, a large number of biological processes, inflammatory diseases, arteriosclerosis, the present invention, the vascular system and circulation salt or a pharmaceutically acceptable compound of formula (I) useful expression for the prevention and treatment of diseases vessel diseases, cancers, tumors, immune system disorders, cell proliferative disorders, infections, etc. I provide. Formula (I): (Wherein, R 2 and R 1 is hydrogen or the like are each independently, X has the formula: is a group of the indicated, X1 is a 6-membered aromatic hydrocarbon ring, a substituted or unsubstituted, X2 is a monocyclic aromatic hydrocarbon ring, a substituted or unsubstituted, R 3 is carboxy, etc. and R 4, hydrogen or the like, is W, the formula:-hydrogen or the like independently, and a, and a group represented by (CR 5 R 6) a-, R 5 ~R 6 is 1 or 2, Y is the formula: is a group of at indicated, halogen, etc. are each independently, is p, R A is an integer from 0 to 6, Z is a cycloalkyl such as substituted or unsubstituted. )本願発明は、PI3Kの作用を阻害し、細胞の成長、分化、生存、増殖、遊走及び代謝等、多数の生物学的プロセスを制御することによって、炎症性疾患、動脈硬化症、血管系・循環器系疾患、がん・腫瘍、免疫系疾患、細胞増殖性疾患、感染症等の疾患の予防・治療のために有用な式(I)で表される化合物又はその薬学的に許容される塩を提供する。式(I):(式中、R1及びR2は、各々独立して水素等、Xは、式:で示される基であり、X1’は、置換もしくは非置換の6員芳香族炭化水素環等、X2’は、置換もしくは非置換の単環式芳香族炭化水素環等、R3は、カルボキシ等、R4は、水素等、Wは、式:-(CR5R6)a-で示される基等、R5~R6は、各々独立して水素等、aは、1又は2、Yは、式:で示される基等であり、RAは、各々独立してハロゲン等、pは、0~6の整数、Zは、置換もしくは非置換のシクロアルキル等である。)