Monoclonal Antibodies specific for the Antigen PIII of Human adenovirus (ADV), produced and secreted by hybridoma CellUseful for the Detection and diagnosis of infection caused by adv
BUENO RAMIREZ, Susan Marcela,KALERGIS PARRA, Alexis Mikes,MORA ALARCON, Jorge Eugenio
申请号：
PE0012942018
公开号：
PE14982018A1
申请日:
2017.01.20
申请国别(地区):
PE
年份:
2018
代理人:
摘要：
Referred to Monoclonal Antibodies or Fragments thereof that bind to Protein of adenovirus (ADV), plllCharacterized in that it comprises a variable region of the heavy chain is a sequence with at least 90%95% or 99% identity with the SEQ ID no: 1, SEQ ID no: 2 and a variable region of the light chain is a sequence with at least 90%95% or 99% identity with the SEQ ID no: 2 or SEQ ID no: 6.It also refers to the nucleotide sequences that define these Antibodies.Methods in vitro and \/ or ex vivo infection diagnosis by ADV in a Biological Sample using these Monoclonal Antibodies, and Diagnostic kits to detect ADV,Comprising at least a monoclonal antibody against ADV.Referido a a anticuerpos monoclonales, o fragmentos de estos, que se unen a la proteina plll del Adenovirus (ADV), caracterizado porque comprende una region variable de la cadena pesada que tiene una secuencia con al menos un 90%, 95% o 99% de identidad con la SEQ ID No: 1 o SEQ ID No: 5 y una region variable de la cadena liviana que tiene una secuencia con al menos un 90%, 95% o 99% de identidad con la SEQ ID No: 2 o SEQ ID No: 6. Tambien se refiere a las secuencias nucleotidicas que definen dichos anticuerpos, metodos in vitro y/o ex vivo de diagnostico de infeccion por ADV en una muestra biologica que utilizan dichos anticuerpos monoclonales y kits de diagnostico para detectar ADV, que comprenden al menos un anticuerpo monoclonal contra ADV.
