Monoclonal antibodies specific for the pIII antigen of human Adenovirus (ADV), produced and secreted by cell hybridomas, useful for detection and diagnosis of ADV infection
Susan Marcela Bueno Ramirez,Alexis Mikes Kalergis Parra,Jorge Eugenio Mora Alarcon
申请号：
US16070730
公开号：
US10766948B2
申请日:
2017.01.20
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention refers to monoclonal antibodies, or fragments thereof, which recognize the pIII protein of the Adenovirus (ADV), useful for developing diagnostic methods of ADV infection in humans. Particularly, it refers to a monoclonal antibody or fragment thereof comprising a variable region of the heavy chain having a sequence with at least a 90%, 95% or 99% of identity with the SEQ ID No: 1 or SEQ ID No: 5 and a variable region of the light chain having a sequence with at least a 90%, 95% or 99% of identity with the SEQ ID No: 2 or SEQ ID No: 6. It also is addressed to the nucleotide sequences which define said antibodies, in vitro and/or ex vivo diagnostic methods of ADV infection in a biological sample using said monoclonal antibodies, and diagnostic kits for detecting ADV comprising at least one monoclonal antibody against ADV according to the above description.
