MAYER, STEVEN L.,KRAVITZ, DAVID C.,MAYER, TRACY H.
申请号：
CA2942689
公开号：
CA2942689A1
申请日:
2014.03.14
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
An apparatus for perfusing an organ or tissue includes a perfusion circuit and a glucose sensor operatively connected to the perfusion circuit. The glucose sensor is configured to detect a target agent that is an indicator of viability of the organ or tissue. The target agent may be Kidney Injury Molecule-1 (KIM-1). The sensor includes a solid support, such as a bead or membrane, to which is attached a recognition molecule that specifically binds to the target agent but not significantly to other agents. The sensor also includes an enzyme that can catalyze the conversion of a substance to glucose. In the presence of the target agent the enzyme can convert the substance into glucose, which can then be detected and optionally be quantified by the sensor.
