#$%^&*AU2018201003A120180301.pdf#####ABSTRACT A method of treating Alzheimer's Disease (AD) with 6-substituted estradiol compounds and their pharmaceutically acceptable salts or prodrugs. The compounds provide for up-regulation of lipoprotein lipase (LPL) and/or apoliprotein C2 (ApoC2), the protein that activates LPL.