The present invention relates to substituted tricyclic pyrazolo-pyrimidine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted tricyclic pyrazolo-pyrimidine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.本發明關於經取代之三環吡唑並-嘧啶化合物類及合成該等化合物之方法。本發明亦關於含有經取代之三環吡唑並-嘧啶化合物類之醫藥組成物及治療細胞增生性疾病(諸如癌症)之方法,該方法係藉由對需要治療之個體給予該等化合物和醫藥組成物。