A dose adjustment mechanism for a drug delivery device, said mechanism comprising an external housing (40; 204), an internal housing (208), an actuator (30; 209) and a selection sleeve (10; 206) disposed between said external housing and said internal housing, wherein the internal housing has an external groove (232), said internal housing being operatively coupled to the actuator (30; 209) and guiding said actuator to dispense a dose adjusted by said mechanism of dose adjustment and wherein said selection sleeve is rotatably engaged with said external groove of said internal housing and in which a dose selection grip (12; 202) is provided rotatably coupled to said selection sleeve (10; 206), said dose selection grip is non-rotationally coupled to a dose knob (5; 216), so that when a dose is adjusted by rotating said dose dose selection grip of said dose adjustment mechanism, said selection sleeve is rotated with respect to said external housing and said internal housing and said selection sleeve is moved away from said external housing and said internal housing.Un mecanismo de ajuste de dosis para un dispositivo de administración de fármacos, comprendiendo dicho mecanismo un alojamiento externo (40; 204), un alojamiento interno (208), un accionador (30; 209) y un manguito de selección (10; 206) dispuesto entre dicho alojamiento externo y dicho alojamiento interno, en el que el alojamiento interno tiene una ranura externa (232), estando dicho alojamiento interno acoplado operativamente al accionador (30; 209) y guiando dicho accionador para dispensar una dosis ajustada por dicho mecanismo de ajuste de dosis y en el que dicho manguito de selección está enganchado de manera rotatoria con dicha ranura externa de dicho alojamiento interno y en el que se proporciona un agarre de selección de dosis (12; 202) acoplado de manera rotatoria a dicho manguito de selección (10; 206), estando acoplado dicho agarre de selección de dosis de manera no rotatoria a un botón de dosific