#$%^&*AU2017204639A120170727.pdf#####15094799_Ld x-7/07/2017 ABSTRACT This invention pertains to pharmaceutical composition comprising a plurality of multilayered beads having an oxycodone layer and a sequestering subunit comprising a naltrexone and a blocking agent, in particular pharmaceutical compositions comprising a higher level of naltrexone, and related compositions and methods of use, such as in the prevention of abuse of a therapeutic agent. The compositions of the present invention also have a long Tmax for oxycodone release and a flatter release profile of oxycodone over time.
