This invention pertains to pharmaceutical composition comprising a plurality of multi layered beads having an oxycodone layer and a sequestering subunit comprising a naltrexone and a blocking agent in particular pharmaceutical compositions comprising a higher level of naltrexone and related compositions and methods of use such as in the prevention of abuse of a therapeutic agent. The compositions of the present invention also have a long T max for oxycodone release and a flatter release profile of oxycodone over time.
