[Overview] [Problem to be Solved] To provide an information processing apparatus, information processing method, and program that make it possible to bring the measurement of the heart rate variability or pulse rate variability of a user freely moving around into a preferable state. [Solution] There is provided an information processing apparatus including: a reliability degree calculation section that calculates a reliability degree of pulsation variability data or a body index; and a control unit that controls various kinds of processing on the basis of the calculated reliability degree. The pulsation variability data is acquired from sensing data acquired by a pulse wave sensor worn by a user. The body index is calculated from the pulsation variability data and indicates a physical state of the user.