COMPOSITION COMPRENANT DES PEPTIDES A AUTO-ASSEMBLAGE DESTINES A ETRE UTILISES DANS LE TRAITEMENT DE LA GINGIVITE, DE LA PARODONTITE ET/OU DE LA PERI-IMPLANTITE
The present invention provides a composition comprisingspecific self-assembling peptides, which are capable of self-assembly at a pHbelow 7.5 and at least physiologic ionic strength, e.g., PI 1-4. PI 1-8, PI 1-14, PI1-13, PI 1-12, PI 1-28, PI 1-29, PI 1-2, PI 1-5, PI 1-17, PI 1-19, PI 1-20, PI1-12,PI 1-16, PI 1-18, PI 1-26 or PI 1-31 for use in treating an oral diseaseselectedfrom the group consisting of gingivitis, periodontitis and/or peri-implantitisina subject. Said composition may be used, after suitable cleaning procedures,for filling pockets formed adjacent to teeth in said diseases, which enhancestissue regeneration. The composition may be suitable for controlled release ofan active agent, e.g., an antimicrobial or antibiotic agent. The inventionalsoprovides a kit suitable for said treatment further comprising self-assemblingpeptides suitable for forming a second layer on top of the first composition.
