ROZEMA DAVID B,LEWIS DAVID L,WAKEFIELD DARREN H,KITAS ERIC A,HADWIGER PHILIPP,WOLFF JON A,ROEHL INGO,MOHR PETER,HOFFMANN TORSTEN,JAHN HOFMANN KERSTIN,MUELLER HANS MARTIN,OTT GUENTHER,BLOKHIN ANDREI V
申请号：
IN4209/DELNP/2013
公开号：
IN2013DN04209A
申请日:
2013.05.10
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
The present invention is directed compositions for delivery of RNA interference (RNAi) polynucleotides to cells in vivo. The compositions comprise amphipathic membrane active poiyamines reversibly modified with enzyme cleavable dipeptide amidobenzyl carbonate masking agents. Modification masks membrane activity of the polymer while reversibility provides physiological responsiveness. The reversibly modified polyamines (dynamic polyconjugate or DPC) are further covalentiy linked to an RNAi polynucleotide or co administered with a targeted RNAi polynucleotide targeting molecule conjugate.
