Embodiments of the present disclosure provides an ultrasonic image analysis system which includes an image collection unit which receives and transmits an ultrasonic waveform and obtains two sets of three-dimensional ultrasonic image data; an image analysis unit which registers the two sets of three-dimensional ultrasonic image data to obtain a registration mapping relationship between the two sets of three-dimensional ultrasonic image data; a user interface unit which responds to a treatment done on the two sets of three-dimensional ultrasonic image data by a user through an external hardware device; an image display unit which displays the two sets of three-dimensional ultrasonic image data according to the registration mapping relationship and a result of the treatment of the user interface unit; and an image store unit for storing the two sets of three-dimensional ultrasonic image data and the registration mapping relationship. Embodiments of the present disclosure also provides an ultrasonic image analysis method. With the present disclosure, therapeutic effect on a patient can be effectively evaluated.