Закрытое акционерное общество Научный Центр "ФармВИЛАР" (RU)
发明人:
Воскобойникова Инна Васильевна (RU),Дружинин Сергей Васильевич (RU)
申请号：
RU2012152604/15
公开号：
RU2012152604A
申请日:
2012.12.06
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A process for preparing lappaconitine hydrobromide by extracting Aconitum roots or northern grasses (Aconitum septentrioale) beloustogo or aconite (Aconitum leucostomum) an organic solvent extract purification treatment lappaconitine solution of hydrobromic acid and crystallization of the expected product, characterized in that the vegetable raw material is carried ekstraktsiyuukazannogo methylene chloride in an apparatus for continuous extraction followed by purification the extract obtained by flash hromatografiey.2. The method of claim 1, wherein as a sorbent for flash chromatography using silica gel and the eluent etilatsetat.3. The method of claim 1, wherein as a sorbent for flash chromatography using alumina as the eluent atseton.4. A process for preparing lappaconitine hydrobromide by extraction of the roots or herbs aconite northern (Aconitum septentrioale) or aconite beloustogo (Aconitum leucostomum) an organic solvent, purifying the extract, processing lappaconitine solution of hydrobromic acid and the desired product crystallisation, characterized in that ekstraktsiyuukazannogo vegetable raw material is carried polar organic solvent, selected from the group consisting of ethanol, acetone, and aqueous solutions thereof, followed by removal of the polar organic extract p astvoritelya, basification and extraction of the resulting residue with dichloromethane, followed by purification the extract obtained by flash hromatografiey.5. A method according to claim 4, wherein as a sorbent for flash chromatography using silica gel and the eluent etilatsetat.6. A method according to claim 4, wherein as a sorbent for fl1. Способ получения лаппаконитина гидробромида путем экстракции корней или травы аконита северного (Aconitum septentrioale) или аконита белоустого (Aconitum leucostomum) органическим растворителем, очистки экстракта, обработки лаппаконитина раствором бромистоводородной кислоты и кристаллизации целевого продукта, отличающийся тем, что экстракциюуказан
