Peter Bernard HEIFETZ,Blanca LLOMPART ROYO,Pablo MARZÁBAL LUNA,Miriam BASTIDA VIRGILI,Mª Dolores LUDEVID MÚGICA,Margarita TORRENT QUETGLAS,Kevin James OCONNER,Roser Pallisse BERGWERF,Mª Immaculada LLO
申请号:
US13166579
公开号:
US20120020992A1
申请日:
2011.06.22
申请国别(地区):
US
年份:
2012
代理人:
摘要:
A fusion protein that is expressed in a recombinant protein body-like assembly (RPBLA) in host eukaryotic cells and organisms is disclosed. More particularly, a biologically active polypeptide fused to a protein sequence that mediates the induction of RPBLA formation is expressed and accumulated in host cells after transformation with an appropriate vector. The eukaryotic host cell does not produce protein bodies in the absence of the fusion protein. Methods for preparing and using the RPBLAs and the fusion protein are also disclosed, as are nucleic acid molecules that encode the fusion proteins.