Oxidized avidin with high residency time in the treated tissues

• 收藏
• 分享

专利权人:

Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.

发明人:

De Santis, Rita,Nuzzolo, Carlo Antonio

申请号：

AU2008281901

公开号：

AU2008281901B2

申请日:

2008.07.16

申请国别(地区):

AU

年份:

2013

代理人:

摘要：

The present invention describes chemically modified avidins that have higherpermanence in treated tissues compared to wild type avidin. Avidin oxidationis performed by periodate incubation in the presence of the low affinity ligandHABA which, occupying the biotin binding sites, prevents protein denaturationduring the oxidation step. Periodate oxidation generates CHO groups from avidinmannose ring opening that, once injected, react with tissue NH

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/