This invention relates to bis-amido pyridines of general formula (I) their use as SMAC mimetics, pharmaceutical compositions containing them, and their use as a medicaments for the treatment and/or prevention of diseases characterized by excessive or abnormal cell proliferation and associated conditions such as cancer.The groups R1 to R4 have the meanings given in the claims and in the specification.本發明係關於通式(I)之雙-醯胺吡啶,其用作SMAC模擬物之用途、含有其之醫藥組合物,及其用作用於治療及/或預防特徵在於過度或異常細胞增殖之疾病及相關病狀(例如癌症)之藥品之用途。基團R1至R4具有申請專利範圍及說明書中所給含義。